OPEN CALLS
DOCTORAL POSITION CohesiNet Doctoral Network
The Oliveira lab has ONE doctoral position open, to begin in September/October 2023, as part of the Horizon Europe Marie Skłodowska-Curie Action Doctoral Network (HE-MSCA DN) of the European Commission entitled “Cohesin and its regulators: from chromosome dynamics and nuclear architecture to human diseases (CohesiNet)".
The offered position will last 36 months. It will allow the recruited researcher to be enrolled in a local PhD school and to participate in an exciting multidisciplinary research programme that will enhance their career perspectives. In addition to his/her individual project, the selected candidate will benefit from a dedicated training programme consisting of local and network-wide training activities aimed at improving their scientific knowledge and transferable skills.
Do you want to join the team?
Benefits
Available project:
Examining the impact of novel cohesion regulators in chromosomal segregation fidelity
Sister chromatid cohesion prevents random chromosome segregation and thereby ensures the fidelity of mitosis. Premature loss of cohesin causes precocious chromatid separation (PCS), resulting in large chromosome segregation defects. Partial loss of cohesin also leads to an increase in susceptibility to errors in chromosome segregation, implying that cohesin decay, even if mild, can compromise mitotic fidelity. Thus, maintenance of sister chromatid cohesion is critical for genome stability and defects in this process have been associated with several human pathologies including birth defects, infertility and cancer. It is therefore important to uncover novel regulators that ensure cohesion maintenance throughout the cell cycle, as well as conditions that improve the fidelity of chromosome segregation in the presence of cohesion defects. Recent work from the Oliveira laboratory (IGC) has uncovered several modulators (enhancers and suppressors) of chromosomal cohesion by means of a genetic screening aimed to identify factors required for mitotic fidelity during Drosophila wing disc development (Silva et al, Curr Biol, 2018). The cell-cycle functions of many of these cohesion modulators are unknown. The proposed project aims to analyse how these factors affect chromosome segregation fidelity in mammalian cells, as well how they mechanistically impact on cohesin dynamics and regulation, at various stages of the cell cycle.
Further details on call, application process and other positions within the network can be found on the following link:
https://euraxess.ec.europa.eu/jobs/66353
For informal enquires, please contact Raquel Oliveira ([email protected])
The offered position will last 36 months. It will allow the recruited researcher to be enrolled in a local PhD school and to participate in an exciting multidisciplinary research programme that will enhance their career perspectives. In addition to his/her individual project, the selected candidate will benefit from a dedicated training programme consisting of local and network-wide training activities aimed at improving their scientific knowledge and transferable skills.
Do you want to join the team?
Benefits
- 3-year full-time employment contract in accordance with the Marie Skłodowska-Curie Action regulations
- Competitive living allowance, mobility allowance and family allowance (if applicable)
- Enrolment in a local PhD school
- Access to state-of-the-art research
- Participation in network-wide training activities, workshops and conferences
- Secondments periods at other network partners’ labs
Available project:
Examining the impact of novel cohesion regulators in chromosomal segregation fidelity
Sister chromatid cohesion prevents random chromosome segregation and thereby ensures the fidelity of mitosis. Premature loss of cohesin causes precocious chromatid separation (PCS), resulting in large chromosome segregation defects. Partial loss of cohesin also leads to an increase in susceptibility to errors in chromosome segregation, implying that cohesin decay, even if mild, can compromise mitotic fidelity. Thus, maintenance of sister chromatid cohesion is critical for genome stability and defects in this process have been associated with several human pathologies including birth defects, infertility and cancer. It is therefore important to uncover novel regulators that ensure cohesion maintenance throughout the cell cycle, as well as conditions that improve the fidelity of chromosome segregation in the presence of cohesion defects. Recent work from the Oliveira laboratory (IGC) has uncovered several modulators (enhancers and suppressors) of chromosomal cohesion by means of a genetic screening aimed to identify factors required for mitotic fidelity during Drosophila wing disc development (Silva et al, Curr Biol, 2018). The cell-cycle functions of many of these cohesion modulators are unknown. The proposed project aims to analyse how these factors affect chromosome segregation fidelity in mammalian cells, as well how they mechanistically impact on cohesin dynamics and regulation, at various stages of the cell cycle.
Further details on call, application process and other positions within the network can be found on the following link:
https://euraxess.ec.europa.eu/jobs/66353
For informal enquires, please contact Raquel Oliveira ([email protected])
